INTRACRANIAL VASCULAR SPASMS
\ˌɪntɹəkɹˈe͡ɪnɪəl vˈaskjʊlə spˈazəmz], \ˌɪntɹəkɹˈeɪnɪəl vˈaskjʊlə spˈazəmz], \ˌɪ_n_t_ɹ_ə_k_ɹ_ˈeɪ_n_ɪ__ə_l v_ˈa_s_k_j_ʊ_l_ə s_p_ˈa_z_ə_m_z]\
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Narrowing of the lumen of one or more intracranial arteries due to contraction of arterial smooth muscle or to morphologic changes of the blood vessel wall. Large blood vessels near the base of the brain are primarily affected and reduced blood flow may result in hypoxic-ischemic brain injury (HYPOXIA-ISCHEMIA, BRAIN). Vasospasm may be associated with SUBARACHNOID HEMORRHAGE; CRANIOCEREBRAL TRAUMA; and other disorders. (From Neurosurg Clin N Am, 1998 Jul;9 (3):615-27)
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.