SLEEP MYOCLONUS SYNDROMES
\slˈiːp mˈa͡ɪəklˌə͡ʊnəs sˈɪndɹə͡ʊmz], \slˈiːp mˈaɪəklˌəʊnəs sˈɪndɹəʊmz], \s_l_ˈiː_p m_ˈaɪ_ə_k_l_ˌəʊ_n_ə_s s_ˈɪ_n_d_ɹ_əʊ_m_z]\
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Excessive periodic leg movements during sleep that cause micro-arousals and interfere with the maintenance of sleep. This condition induces a state of relative sleep deprivation which manifests as excessive daytime hypersomnolence. The movements are characterized by repetitive contractions of the tibialis anterior muscle, extension of the toe, and intermittent flexion of the hip, knee and ankle. (Adams et al., Principles of Neurology, 6th ed, p387)
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Word of the day
Dopamine Acetyltransferase
- An enzyme that catalyzes the of groups from acetyl-CoA to arylamines. They have wide specificity for aromatic amines, particularly serotonin, and can also catalyze acetyl transfer between arylamines without CoA. EC 2.3.1.5.