SILVER AGE

\sˈɪlvəɹ ˈe͡ɪd͡ʒ], \sˈɪlvəɹ ˈe‍ɪd‍ʒ], \s_ˈɪ_l_v_ə_ɹ ˈeɪ_dʒ]\
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Platidiam

  • An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.
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