REGINA MARIA ROCHE

\ɹɪd͡ʒˈa͡ɪnə mɐɹˈiːə ɹˈɒt͡ʃ], \ɹɪd‍ʒˈa‍ɪnə mɐɹˈiːə ɹˈɒt‍ʃ], \ɹ_ɪ_dʒ_ˈaɪ_n_ə m_ɐ_ɹ_ˈiː__ə ɹ_ˈɒ_tʃ]\
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1910 - Warner's dictionary of authors ancient and modern
By Charles Dudley Warner

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Platidiam

  • An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.
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