PICK DISEASE OF THE BRAIN
\pˈɪk dɪzˈiːz ɒvðə bɹˈe͡ɪn], \pˈɪk dɪzˈiːz ɒvðə bɹˈeɪn], \p_ˈɪ_k d_ɪ_z_ˈiː_z ɒ_v_ð_ə b_ɹ_ˈeɪ_n]\
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A rare form of DEMENTIA that is sometimes familial. Clinical features include APHASIA; APRAXIA; CONFUSION; ANOMIA; memory loss; and personality deterioration. This pattern is consistent with the pathologic findings of circumscribed atrophy of the poles of the FRONTAL LOBE and TEMPORAL LOBE. Neuronal loss is maximal in the HIPPOCAMPUS, entorhinal cortex, and AMYGDALA. Some ballooned cortical neurons contain argentophylic (Pick) bodies. (From Brain Pathol 1998 Apr;8 (2):339-54; Adams et al., Principles of Neurology, 6th ed, pp1057-9)
By DataStellar Co., Ltd
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