PENNSYLVANIA GAZETTE
\pˌɛnsɪlvˈe͡ɪni͡ə ɡəzˈɛt], \pˌɛnsɪlvˈeɪniə ɡəzˈɛt], \p_ˌɛ_n_s_ɪ_l_v_ˈeɪ_n_iə ɡ_ə_z_ˈɛ_t]\
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A semi-weekly newspaper established at Philadelphia December 24, 1728, by Samuel Keimer. The full title was The Universal Instructor in all Arts and Sciences and Pennsylvania Gazette. Keimer soon turned it over to the management of his apprentice, Benjamin Franklin, who quickly made it the most valuable newspaper property in this country. The semi-weekly publication was, however, changed to a weekly, owing to lack of subscription. Franklin retired from the management of the Gazette in 1766. The Gazette did good service to the Revolutionary cause until the British occupation of Philadelphia. Publication was suspended until after evacuation. It was then renewed and survived another brief suspension in 1815. The first part of the title was dropped when Franklin assumed the management. In 1845 the Gazette was merged in the Daily North American, which is still published.
By John Franklin Jameson
Word of the day
Proto Oncogene Proteins c erbB 2
- cell surface protein-tyrosine kinase that is found to be overexpressed in significant number adenocarcinomas. It has extensive homology can heterodimerize EGF EPIDERMAL GROWTH FACTOR), 3 receptor (RECEPTOR, 3) and the 4 receptor. Activation of erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB family members. EC 2.7.11.-.