NOVOTHYRAL
\nˈɒvəθˌɪɹə͡l], \nˈɒvəθˌɪɹəl], \n_ˈɒ_v_ə_θ_ˌɪ_ɹ_əl]\
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The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.
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