MPTP POISONING
\ˌɛmpˌiːtˌiːpˈiː pˈɔ͡ɪzənɪŋ], \ˌɛmpˌiːtˌiːpˈiː pˈɔɪzənɪŋ], \ˌɛ_m_p_ˌiː_t_ˌiː_p_ˈiː p_ˈɔɪ_z_ə_n_ɪ_ŋ]\
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A condition caused by the neurotoxin 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE. MPTP causes selective destruction of nigrostriatal dopaminergic neurons. Clinical features include irreversible parkinsonian signs including rigidity and bradykinesia (PARKINSON DISEASE, SECONDARY). MPTP toxicity is also used as an animal model for the study of PARKINSON DISEASE. (Adams et al., Principles of Neurology, 6th ed, p1072; Neurology 1986 Feb;36 (2):250-8)
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Word of the day
Dopamine Acetyltransferase
- An enzyme that catalyzes the of groups from acetyl-CoA to arylamines. They have wide specificity for aromatic amines, particularly serotonin, and can also catalyze acetyl transfer between arylamines without CoA. EC 2.3.1.5.