LEBER HEREDITARY OPTIC NEUROPATHY
\lˈɛbə hɪɹˈɛdɪtəɹi ˈɒptɪk njuːɹˈɒpəθɪ], \lˈɛbə hɪɹˈɛdɪtəɹi ˈɒptɪk njuːɹˈɒpəθɪ], \l_ˈɛ_b_ə h_ɪ_ɹ_ˈɛ_d_ɪ_t_ə_ɹ_i_ ˈɒ_p_t_ɪ_k n_j_uː_ɹ_ˈɒ_p_ə_θ_ɪ]\
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A maternally linked genetic disorder that presents in mid-life as acute or subacute central vision loss leading to central scotoma and blindness. The disease has been associated with missense mutations in the mtDNA, in genes for Complex I, III, and IV polypeptides, that can act autonomously or in association with each other to cause the disease. (from Online Mendelian Inheritance in Man, http://www.ncbi.nlm.nih.gov/Omim/, MIM#535000 (April 17, 2001))
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.
Nearby Words
- lebban
- lebbeus
- leben
- lebensraum
- leber hereditary optic atrophy
- Leber Hereditary Optic Neuropathy
- leber optic atrophy
- leber's disease
- leber's disease's plexus
- leberecht uhlich
- leberidocytes