INTEMPERAMENT

\ɪntˈɛmpɹəmənt], \ɪntˈɛmpɹəmənt], \ɪ_n_t_ˈɛ_m_p_ɹ_ə_m_ə_n_t]\
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1790 - A Complete Dictionary of the English Language
By Thomas Sheridan

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Platidiam

  • An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.
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