INDIAN HEALTH SERVICE (U.S.)
\ˈɪndi͡ən hˈɛlθ sˈɜːvɪs jˌuːˈɛs], \ˈɪndiən hˈɛlθ sˈɜːvɪs jˌuːˈɛs], \ˈɪ_n_d_iə_n h_ˈɛ_l_θ s_ˈɜː_v_ɪ_s__ j_ˌuː_ˈɛ_s]\
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.
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