ICI69653
\ˈa͡ɪsa͡ɪ sˈɪkstinˈa͡ɪn θˈa͡ʊzənd sˈɪkshˈʌndɹədən fˈɪftiθɹˈiː], \ˈaɪsaɪ sˈɪkstinˈaɪn θˈaʊzənd sˈɪkshˈʌndɹədən fˈɪftiθɹˈiː], \ˈaɪ_s_aɪ s_ˈɪ_k_s_t_i_n_ˈaɪ_n θ_ˈaʊ_z_ə_n_d_ s_ˈɪ_k_s_h_ˈʌ_n_d_ɹ_ə_d_ə_n f_ˈɪ_f_t_i_θ_ɹ_ˈiː]\
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An antiviral antibiotic produced by Cephalosporium aphidicola and other fungi. It inhibits the growth of eukaryotic cells and certain animal viruses by selectively inhibiting the cellular replication of DNA polymerase II or the viral-induced DNA polymerases. The drug may be useful for controlling excessive cell proliferation in patients with cancer, psoriasis or other dermatitis with little or no adverse effect upon non-multiplying cells.
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.