DELTA 13 PG REDUCTASE
\dˈɛltə θˈɜːtiːn pˌiːd͡ʒˈiː ɹɪdˈʌkte͡ɪs], \dˈɛltə θˈɜːtiːn pˌiːdʒˈiː ɹɪdˈʌkteɪs], \d_ˈɛ_l_t_ə θ_ˈɜː_t_iː_n p_ˌiː_dʒ_ˈiː ɹ_ɪ_d_ˈʌ_k_t_eɪ_s]\
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(5Z)- (15S)-11 alpha-Hydroxy-9,15-dioxoprostanoate:NAD (P)+ delta (13)-oxidoreductase. An enzyme active in prostaglandin E and F catabolism. It catalyzes the reduction of the double bond at the 13-14 position of the 15-ketoprostaglandins and uses NADPH as cofactor. EC 1.3.1.48.
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.