CHILDHOOD TYPE DERMATOMYOSITIDES
\t͡ʃˈa͡ɪldhʊd tˈa͡ɪp dˈɜːmɐtˌɒmɪˌɒsɪtˌa͡ɪdz], \tʃˈaɪldhʊd tˈaɪp dˈɜːmɐtˌɒmɪˌɒsɪtˌaɪdz], \tʃ_ˈaɪ_l_d_h_ʊ_d t_ˈaɪ_p d_ˈɜː_m_ɐ_t_ˌɒ_m_ɪ__ˌɒ_s_ɪ_t_ˌaɪ_d_z]\
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A subacute or chronic inflammatory disease of muscle and skin, marked by proximal muscle weakness and a characteristic skin rash. The illness occurs with approximately equal frequency in children and adults. The skin lesions usually take the form of a purplish rash (or less often an exfoliative dermatitis) involving the nose, cheeks, forehead, upper trunk, and arms. The disease is associated with a complement mediated intramuscular microangiopathy, leading to loss of capillaries, muscle ischemia, muscle-fiber necrosis, and perifascicular atrophy. The childhood form of this disease tends to evolve into a systemic vasculitis. Dermatomyositis may occur in association with malignant neoplasms. (From Adams et al., Principles of Neurology, 6th ed, pp1405-6)
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Word of the day
Dopamine Acetyltransferase
- An enzyme that catalyzes the of groups from acetyl-CoA to arylamines. They have wide specificity for aromatic amines, particularly serotonin, and can also catalyze acetyl transfer between arylamines without CoA. EC 2.3.1.5.