CAFFEINE DEMETHYLASE
\kˈafiːn dˈɛmiːθˌɪle͡ɪs], \kˈafiːn dˈɛmiːθˌɪleɪs], \k_ˈa_f_iː_n d_ˈɛ_m_iː_θ_ˌɪ_l_eɪ_s]\
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A polycyclic aromatic hydrocarbon-inducible cytochrome which is of significant clinical interest due to the large number of drug interactions associated with induction and inhibition of theophylline. Caffeine is considered to be a model substrate for this enzyme. It also metabolizes theophylline and antipyrene. Environmental factors including cigarette smoking, charbroiled meat, cruciferous vegetables, and a number of drugs including phenytoin, phenobarbital, and omeprazole produce increases in CYP1A2 activity. (Ann Pharmacother 1995;29:619-24) EC 1.-.
By DataStellar Co., Ltd
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