BORRELIA BURGDORFERI NEUROBORRELIOSIS
\bˈɒɹɪlˌa͡ɪə bˈɜːɡdɔːfəɹˌi njˌuːɹəbˌɒɹɪlɪˈə͡ʊsɪs], \bˈɒɹɪlˌaɪə bˈɜːɡdɔːfəɹˌi njˌuːɹəbˌɒɹɪlɪˈəʊsɪs], \b_ˈɒ_ɹ_ɪ_l_ˌaɪ_ə b_ˈɜː_ɡ_d_ɔː_f_ə_ɹ_ˌi n_j_ˌuː_ɹ_ə_b_ˌɒ_ɹ_ɪ_l_ɪ__ˈəʊ_s_ɪ_s]\
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Nervous system infections caused by tick-borne spirochetes of the BORELLIA BORGDORFERI GROUP. The disease may affect elements of the central or peripheral nervous system in isolation or in combination. Common clinical manifestations include a lymphocytic meningitis, cranial neuropathy (most often a facial neuropathy), POLYRADICULOPATHY, and a mild loss of memory and other cognitive functions. Less often more extensive inflammation involving the central nervous system (encephalomyelitis) may occur. In the peripheral nervous system, B. burgdorferi infection is associated with mononeuritis multiplex and polyradiculoneuritis. (From J Neurol Sci 1998 Jan 8;153 (2):182-91)
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.