ALKAPTONURIA
\ˌalkɐptənjˈʊɹi͡ə], \ˌalkɐptənjˈʊɹiə], \ˌa_l_k_ɐ_p_t_ə_n_j_ˈʊ_ɹ_iə]\
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By Princeton University
By DataStellar Co., Ltd
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An inborn error of amino acid metabolism resulting from a defect in the enzyme homogentisate 1,2-dioxygenase and causing an accumulation of homogentisic acid in the urine. The condition is characterized by ochronosis in various tissues and arthritis.
By DataStellar Co., Ltd
By Willam Alexander Newman Dorland
Word of the day
Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.