PYRIMIDINE DIMERS
\pˈɪɹɪmˌɪdiːn dˈa͡ɪməz], \pˈɪɹɪmˌɪdiːn dˈaɪməz], \p_ˈɪ_ɹ_ɪ_m_ˌɪ_d_iː_n d_ˈaɪ_m_ə_z]\
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Dimers found in DNA chains damaged by ultraviolet irradiation. They consist of two adjacent pyrimidine nucleotides, usually thymine nucleotides, in which the pyrimidine residues are covalently joined by a cyclobutane ring. These dimers stop DNA replication.
By DataStellar Co., Ltd
Word of the day
Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.