MEDIAL CALCIFIC SCLEROSES
\mˈiːdiːəl kalsˈɪfɪk sklˈɛɹə͡ʊzɪz], \mˈiːdiːəl kalsˈɪfɪk sklˈɛɹəʊzɪz], \m_ˈiː_d_iː__ə_l k_a_l_s_ˈɪ_f_ɪ_k s_k_l_ˈɛ_ɹ_əʊ_z_ɪ_z]\
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Thickening and loss of elasticity of arterial walls. Atherosclerosis is the most common form of arteriosclerosis and involves lipid deposition and thickening of the intimal cell layers within arteries. Additional forms of arteriosclerosis involve calcification of the media of muscular arteries (Monkeberg medial calcific sclerosis) and thickening of the walls of small arteries or arterioles due to cell proliferation or hyaline deposition (arteriolosclerosis).
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Platidiam
- An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.