LAUGHTON OSBORN

\lˈaftən ˈɒsbɔːn], \lˈaftən ˈɒsbɔːn], \l_ˈa_f_t_ə_n ˈɒ_s_b_ɔː_n]\
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1910 - Warner's dictionary of authors ancient and modern
By Charles Dudley Warner

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Platidiam

  • An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.
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