COAKLEY OPERATION

\kˈə͡ʊklɪ ˌɒpəɹˈe͡ɪʃən], \kˈə‍ʊklɪ ˌɒpəɹˈe‍ɪʃən], \k_ˈəʊ_k_l_ɪ_ ˌɒ_p_ə_ɹ_ˈeɪ_ʃ_ə_n]\

Definitions of COAKLEY OPERATION

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Platidiam

  • An inorganic water-soluble platinum complex. After undergoing hydrolysis, it reacts DNA produce both intra interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity cisplatin correlates with cellular arrest in G2 phase cell cycle.
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