AMYLOID A4 PROTEIN PRECURSOR
\ˈamɪlˌɔ͡ɪd ˌe͡ɪ fˈɔː pɹˈə͡ʊtiːn pɹɪkˈɜːsə], \ˈamɪlˌɔɪd ˌeɪ fˈɔː pɹˈəʊtiːn pɹɪkˈɜːsə], \ˈa_m_ɪ_l_ˌɔɪ_d ˌeɪ f_ˈɔː p_ɹ_ˈəʊ_t_iː_n p_ɹ_ɪ_k_ˈɜː_s_ə]\
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A precursor to the AMYLOID-BETA PROTEIN (beta/A4). Alterations in the expression of the amyloid beta-protein precursor (ABPP) gene, located on chromosome 21, plays a role in the development of the neuropathology common to both ALZHEIMER DISEASE and DOWN SYNDROME. ABPP is associated with the extensive extracellular matrix secreted by neuronal cells. Upon cleavage, this precursor produces three proteins of varying amino acid lengths: 695, 751, and 770. The beta/A4 (695 amino acids) or beta-amyloid protein is the principal component of the extracellular amyloid in senile plaques found in ALZHEIMER DISEASE; DOWN SYNDROME and, to a limited extent, in normal aging.
By DataStellar Co., Ltd
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